background:
Piezos are large transmembrane proteins conserved among various species, all having between 24 and 36 predicted transmembrane domains. 'Piezo' comes from the Greek 'piesi,' meaning 'pressure.' The FAM38A gene encodes PIEZO1, a protein that induces mechanically activated (MA) currents in various cell types (Coste et al., 2010 [PubMed 20813920]).[supplied by OMIM, Nov 2010]
Function:
Component of mechanosensitive channel required for the mechanosensitive currents. Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling.
Subcellular Location:
Endoplasmic reticulum membrane. Endoplasmic reticulum-Golgi intermediate compartment membrane. Cell membrane.
Tissue Specificity:
Expressed in numerous tissues. In normal brain, expressed exclusively in neurons, not in astrocytes. In Alzheimer disease brains, expressed in about half of the activated astrocytes located around classical senile plaques. In Parkinson disease substantia nigra, not detected in melanin-containing neurons nor in activated astrocytes.
Similarity:
Belongs to the PIEZO family.
Database links:
Entrez Gene: 9780 Human
Entrez Gene: 234839 Mouse
Entrez Gene: 361430 Rat
Omim: 611184 Human
SwissProt: Q92508 Human
SwissProt: E2JF22 Mouse
SwissProt: Q0KL00 Rat
Unigene: 377001 Human
Unigene: 592074 Human
Unigene: 37324 Mouse
Unigene: 20892 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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