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Rabbit Anti-CACNB3/FITC Conjugated antibody
background:
Voltage-dependent calcium channels are essential for the release of neurotransmitters. L-type (long lasting current) voltage-dependent calcium channels are composed of four subunits: an Alpha1 subunit, a Beta subunit, a Beta subunit and an Alpha2 Gamma subunit. The Beta subunit is encoded by four genes, designated Beta1-Beta4, all of which contribute to the diversity of calcium currents and are involved in membrane trafficking of the Beta subunit. L-type Ca++ CP Beta3, also known as CACNB3 (Calcium channel voltage-dependent subunit beta 3), CACNLB3 or CAB3, is a 484 amino acid protein that contains one SH3 domain and is expressed in ovary, brain and smooth muscle. Functioning as one of the four components of the Beta subunit, L-type Ca++ CP Beta 3 increases the peak calcium current in voltage-dependent calcium channels, thereby shifting the voltage dependencies of activation and inactivation and controlling G protein inhibition and Beta membrane targeting. Two isoforms of L-type Ca++ CP Beta3 exist due to alternative splicing events.
Function:
The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.
Subunit:
The L-type calcium channel is composed of four subunits: alpha-1, alpha-2, beta and gamma. Interacts with CACNA2D4. Interacts with FASLG.
Tissue Specificity:
Expressed mostly in brain, smooth muscle and ovary.
Similarity:
Belongs to the calcium channel beta subunit family.
Contains 1 SH3 domain.
Database links:
Entrez Gene: 784 Human
Entrez Gene: 12297 Mouse
Entrez Gene: 25297 Rat
Omim: 601958 Human
SwissProt: P54284 Human
SwissProt: P54285 Mouse
SwissProt: P54287 Rat
Unigene: 250712 Human
Unigene: 3544 Mouse
Unigene: 2808 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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