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Rabbit Anti-FAM162A/FITC Conjugated antibody
background:
HGTD-P (human growth and transformation-dependent protein), also known as E2IG5 or FAM162A, is a 154 amino acid single-pass membrane protein belonging to the UPF0389 family. Considered a proapoptotic protein, HGTD-P is an effector of cell death induced by hypoxia-ischemia (HI) and is therefore considered a potential target in treating HI-induced brain damage. HGTD-P localizes to the mitochondria and, when overexpressed, induces the mitochondrial permeability transition by interacting with voltage dependent anion channels. HGTD-P facilitates apoptotic cell death via the mitochondrial apoptotic cascades, including permeability transition, cytochrome c release and caspase 9 activation. HGTD-P is regulated and activated by HIF-1?through a hypoxia-responsive element on the HGTD-P promoter region.
Subcellular Location:
Membrane.
Similarity:
Belongs to the UPF0389 family.
Database links:
Entrez Gene: 26355 Human
Omim: 608017 Human
SwissProt: Q96A26 Human
Unigene: 584881 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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