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Rabbit Anti-FAM125A/FITC Conjugated antibody
background:
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in the ligand-mediated internalization and down-regulation of EGF receptor.
Subcellular Location:
Cytoplasm. Nucleus. Endosome. Cytoplasm > cytoskeleton > centrosome. Late endosome membrane. Colocalizes with F-actin. Some fraction may be nuclear.
Tissue Specificity:
Ubiquitously expressed except in skeletal muscle.
Post-translational modifications:
Phosphorylated on Tyr-204 upon EGF stimulation. Phosphorylation is required for interaction with CD2AP and CIN85/SH3KBP1.
Similarity:
Belongs to the FAM125 family.
Contains 1 MABP domain.
Contains 1 UMA domain.
Database links:
Entrez Gene: 93343 Human
SwissProt: Q96EY5 Human
Unigene: 515243 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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