background:
The X and Y chromosomes are the human sex chromosomes. Chromosome X consists of about 153 million base pairs and nearly 1,000 genes. The combination of an X and Y chromosome lead to normal male development while two copies of X lead to normal female development. There are a number of conditions related to an unsual number and combination of sex chromosomes being inherited. More than one copy of the X chromosome with a Y chromosome causes Klinefelter's syndrome. A single copy of X alone leads to Turner's syndrome. More than 2 copies of the X chromosome, in the absence of a Y chromosome, is known as Triple X syndrome. Color blindness, hemophilia, and Duchenne muscular dystrophy are well known X chromosome-linked conditions which affect males more frequently as males carry a single X chromosome. The FAM122B gene product has been provisionally designated FAM122B pending further characterization.
Post-translational modifications:
Isoform 3 and isoform 4 are phosphorylated on Ser-62 and Ser-64.
Similarity:
Belongs to the FAM122 family.
Database links:
Entrez Gene: 159090 Human
SwissProt: Q7Z309 Human
Unigene: 404706 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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