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Rabbit Anti-PER-3/FITC Conjugated antibody
background:
This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. Circadian expression in the suprachiasmatic nucleus continues in constant darkness, and a shift in the light/dark cycle evokes a proportional shift of gene expression in the suprachiasmatic nucleus. The specific function of this gene is not yet known. [provided by RefSeq, Jul 2008]
Function:
Component of the circadian clock mechanism which is essential for generating circadian rhythms. Can bind heme.
Subcellular Location:
Cytoplasm. Nucleus. Mainly cytoplasmic. Translocates to the nucleus through binding PER1, PER2, CRY1 or CRY2, but not TIMELESS.
Post-translational modifications:
Phosphorylation appears to require association with PER1 and translocation to the nucleus.
Ubiquitinated.
Similarity:
Contains 1 PAC (PAS-associated SLCterminal) domain.
Contains 2 PAS (PER-ARNT-SIM) domains.
Database links:
Entrez Gene: 8863 Human
Entrez Gene: 18628 Mouse
Entrez Gene: 78962 Rat
Omim: 603427 Human
SwissProt: P56645 Human
SwissProt: O70361 Mouse
SwissProt: Q8CJE2 Rat
Unigene: 16440 Human
Unigene: 121361 Mouse
Unigene: 230006 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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