background:
With 181 million base pairs encoding around 1,000 genes, chromosome 5 is about 6% of human genomic DNA. It is associated with Cockayne syndrome through the ERCC8 gene and familial adenomatous polyposis through the adenomatous polyposis coli (APC) tumor suppressor gene. Treacher Collins syndrome is also chromosome 5 associated and is caused by insertions or deletions within the TCOF1 gene. Deletion of the p arm of chromosome 5 leads to Cri du chat syndrome. Deletion of 5q or chromosome 5 altogether is common in therapy-related acute myelogenous leukemias and myelodysplastic syndrome. The FAM105A gene product has been provisionally designated FAM105A pending further characterization.
Similarity:
Belongs to the FAM105 family.
Database links:
Entrez Gene: 54491 Human
Entrez Gene: 223433 Mouse
Entrez Gene: 310190 Rat
SwissProt: Q9NUU6 Human
SwissProt: Q3TVP5 Mouse
SwissProt: Q3B7D8 Rat
Unigene: 155085 Human
Unigene: 266485 Mouse
Unigene: 162566 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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