background:
This gene encodes an ankyrin repeat protein that belongs to the death receptor-associated family of proteins and plays a role in mediating apoptosis. The encoded protein is also thought to function in the replication stress-induced checkpoint signaling pathway via interaction with checkpoint kinase 1. [provided by RefSeq, Aug 2013]
Subcellular Location:
Cytoplasm. Nucleus. Note: In the nucleus, the protein level increased slightly after camptothecin (CPT) treatment. Associated with chromatin.
Tissue Specificity:
Widely expressed. Highly expressed in testis. Weakly expressed in other tissues.
Similarity:
Belongs to the fem-1 family.
Contains 8 ANK repeats.
Contains 1 TPR repeat.
Database links:
Entrez Gene: 10116 Human
Entrez Gene: 415559 Chicken
Entrez Gene: 14155 Mouse
Entrez Gene: 315745 Rat
Omim: 613539 Human
SwissProt: Q5ZM55 Chicken
SwissProt: Q9UK73 Human
SwissProt: Q9Z2G0 Mouse
SwissProt: P0C6P7 Rat
Unigene: 362733 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
|
|