Home > Product > Antibody > Rabbit Anti-EXOC7/FITC Conjugated antibody
2 5 3p; DKFZp686J04253; EX070; EXO70; Exo70p; EXOC 1; EXOC 7; EXOC1; Exoc7; EXOC7_HUMAN; Exocyst complex component 7; Exocyst complex component Exo70; FLJ40965; FLJ46415; KIAA1067; Rexo70; YJL085W.
Cat:
SL14664R-FITC
Species Reactivity:
(predicted: Human,Mouse,Rat,Chicken,Cow,Horse,Rabbit,)
Immunogen:
KLH conjugated synthetic peptide derived from human EXOC7
Format:
Lyophilized or Liquid
Storage instructions:
Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant
Buffer:
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Concentration:
1mg/ml
Clonality:
Polyclonal
Isotype:
IgG
Applications:
ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.
Host:
Rabbit
Calculated MW:
83kDa
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Unit:
Price: $
Product PDFs
Datasheet:


background:
The protein encoded by this gene is a component of the exocyst complex. The exocyst complex plays a critical role in vesicular trafficking and the secretory pathway by targeting post-Golgi vesicles to the plasma membrane. The encoded protein is required for assembly of the exocyst complex and docking of the complex to the plasma membrane. The encoded protein may also play a role in pre-mRNA splicing through interactions with pre-mRNA-processing factor 19. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 4. [provided by RefSeq, Nov 2011]

Function:
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. In adipocytes, plays a crucial role in targeting SLC2A4 vesicle to the plasma membrane in response to insulin, perhaps directing the vesicle to the precise site of fusion.

Subcellular Location:
Cytoplasm > cytosol. Cell membrane. Translocates, as a preformed complex with SEC6 and SEC8, to the plasma membrane in response to insulin through the activation of ARHQ.

Similarity:
Belongs to the EXO70 family.

Database links:

Entrez Gene: 23265 Human

Entrez Gene: 417361 Chicken

Entrez Gene: 505568 Cow

Entrez Gene: 53413 Mouse

Entrez Gene: 64632 Rat

Entrez Gene: 406723 Zebrafish

Omim: 608163 Human

SwissProt: Q5ZIN3 Chicken

SwissProt: Q3ZC43 Cow

SwissProt: Q9UPT5 Human

SwissProt: O35250 Mouse

SwissProt: O54922 Rat

SwissProt: Q7ZTX5 Zebrafish

Unigene: 514496 Human

Unigene: 533985 Human

Unigene: 22530 Mouse

Unigene: 45761 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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