background:
This gene is located at the 5' end of the HOXD gene cluster on chromosome 2. The encoded protein is a homeobox transcription factor that is related to the protein encoded by the Drosophila even-skipped (eve) gene, a member of the pair-rule class of segmentation genes. A 117 kb microdeletion at the 5' end of the HOXD gene cluster, which includes this gene and the HOXD9-HOXD13 genes, causes synpolydactyly, a dominantly inherited disease resulting in limb malformation. [provided by RefSeq, Sep 2009]
Function:
EVX2 (Even skipped homeobox 2) protein is a new candidate transcription factor. It contains a homeobox DNA-binding domain.
Subcellular Location:
Nuclear
Similarity:
Belongs to the even-skipped homeobox family.
Contains 1 homeobox DNA-binding domain.
Database links:
Entrez Gene: 344191 Human
Entrez Gene: 14029 Mouse
Entrez Gene: 288155 Rat
Omim: 142991 Human
SwissProt: Q03828 Human
SwissProt: P49749 Mouse
Unigene: 452341 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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