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Rabbit Anti-CD361/FITC Conjugated antibody
background:
EVI2B is a 448 amino acid protein which functions in the differentiation of melanocytes and keratinocytes. Lying within an intron of the Neurofibromin gene, the gene encoding EVI2B is transcribed from the telomere toward the centromere, which is opposite the transcription direction of the Neurofibromin gene. EVI2B is a single-pass transmembrane protein containing an extracellular domain with 4 glycosylation sites, a N-terminal signal peptide, a cytoplasmic hydrophilic domain and a hydrophobic transmembrane domain. Due to evidence suggesting that gene encoding the mouse homolog lies within a viral integration site that has been identitified in retrovirus-induced myeloid tumors, the gene encoding EVI2B may function as an oncogene in these tumor types. With expression in peripheral blood mononuclear cells, fibroblasts, bone marrow and EBSLVtransformed lymphoblastoid cell lines, EVI2B is implicated in leukemogenesis.
Subcellular Location:
Membrane.
Tissue Specificity:
Bone marrow, peripheral blood mononuclear cells, fibroblasts and Epstein-Barr virus-transformed lymphoblastoid cell lines.
Database links:
Entrez Gene: 2124 Human
Omim: 158381 Human
SwissProt: P34910 Human
Unigene: 5509 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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