Rabbit Anti-KCNIP4/FITC Conjugated antibody

Home > Product > Antibody > Rabbit Anti-KCNIP4/FITC Conjugated antibody

A type potassium channel modulatory protein 4; a-type potassium channel modulatory protein 4; CALP; calsenilin like protein; Calsenilin-like protein; HGNC:30083; KCHIP 4; KCHIP4; KCIP4_HUMAN; KCNIP 4; Kcnip4; Kv channel interacting protein 4;

Cat:

SL14646R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Dog,Cow,)

Immunogen：

KLH conjugated synthetic peptide derived from human KCNIP4

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

29kDa

prev next

Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
Feedback Wall

background:
This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. This protein member also interacts with presenilin. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Function:
Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Probably modulates channels density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND2/Kv4.2 and KCND3/Kv4.3 currents.

Subcellular Location:
Cell membrane.

Tissue Specificity:
Predominantly expressed in brain.

Similarity:
Belongs to the recoverin family.
Contains 4 EF-hand domains.

Database links:

Entrez Gene: 614299 Cow

Entrez Gene: 80333 Human

Entrez Gene: 80334 Mouse

Entrez Gene: 259243 Rat

Omim: 608182 Human

SwissProt: Q2KI69 Cow

SwissProt: Q6PIL6 Human

SwissProt: Q6PHZ8 Mouse

SwissProt: Q99MG9 Rat

Unigene: 655705 Human

Unigene: 160172 Mouse

Unigene: 205864 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Product Feedback Wall