background:
FAM5C belongs to the FAM5 family.
Function:
Inhibits neuronal cell proliferation by negative regulation of the cell cycle transition. Promotes pituitary gonadotrope cell proliferation, migration and invasion, when overexpressed. May play a role in cell pituitary tumor development.
Subcellular Location:
Secreted
Tissue Specificity:
Strongly expressed in oral keratinocytes compared to the weak expression in tongue squamous cell carcinoma (SCC). Expressed in endothelial and aortic smooth muscle cells. Overexpressed in gonadotropinomas compared to normal pituitarie tissues.
Similarity:
Belongs to the BRINP family.
Contains 1 MACPF domain.
Database links:
Entrez Gene: 339479 Human
SwissProt: Q76B58 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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