background:
FIBIN (Fin bud initiation factor homolog) is a 211 amino acid protein involved in fin initiation in zebrafish. The human homolog is encoded by a gene that maps to chromosome 11, which makes up around 4% of human genomic DNA and is considered a gene and disease association dense chromosome. The chromosome 11 encoded Atm gene is important for regulation of cell cycle arrest and apoptosis following double strand DNA breaks. Atm mutation leads to the disorder known as ataxia-telangiectasia. The blood disorders Sickle cell anemia and β thalassemia are caused by HBB gene mutations. Wilms' tumors, WAGR syndrome and Denys-Drash syndrome are associated with mutations of the WT1 gene. Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema and Smith-Lemli-Opitz syndrome are also associated with defects in chromosome 11.
Subcellular Location:
Secreted. Golgi apparatus.
Similarity:
Belongs to the FIBIN family.
Database links:
Entrez Gene: 387758 Human
Entrez Gene: 451086 Chimpanzee
Entrez Gene: 507975 Cow
Entrez Gene: 100057578 Horse
Entrez Gene: 67606 Mouse
Entrez Gene: 499856 Rat
Entrez Gene: 699699 Rhesus monkey
SwissProt: Q5E9H1 Cow
SwissProt: A4UZ23 Horse
SwissProt: Q8TAL6 Human
SwissProt: Q9CQS3 Mouse
SwissProt: Q5U2T4 Rat
Unigene: 712718 Human
Unigene: 29369 Mouse
Unigene: 43451 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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