Rabbit Anti-FLJ14213/FITC Conjugated antibody

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FLJ14213 protein; Hypothetical protein FLJ14213; Hypothetical protein LOC79899; Proline-rich protein 5-like; Protein observed with Rictor-2; Protor 2; Protor-2; PROTOR2; PRR5L; PRR5L_HUMAN.

Cat:

SL16107R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Dog,Cow,Horse,Rabbit,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human FLJ14213

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

41kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
mTOR is a large protein kinase that is important in cell growth and functions as the mammalian target of Rapamycin, an immunosuppressant that blocks vessel restenosis and also has potential anticancer applications. Rapamycin-insensitive companion of mTOR, also designated Rictor, forms a complex (designated mTORC2) with mTOR that directly phosphorylates Akt/PKB on Ser473 and plays a key role in growth signaling pathways. Protor-2, also known as PROTOR2 or FLJ14213, is a 368 amino acid protein that is thought to interact with the mTORC2 complex and, via this interaction, may regulate organization of the Actin cytoskeleton. Three isoforms of Protor-2 are expressed due to alternative splicing events.

Function:
May be part of the TORC2 complex which plays a critical role in AKT1 'Ser-473' phosphorylation, and may modulate the phosphorylation of PKCA and regulate actin cytoskeleton organization.

Subunit:
Interacts with the mammalian target of rapamycin complex 2 (mTORC2) which contains MTOR, MLST8, PRR5, RICTOR, MAPKAP1 and DEPTOR. Interacts with RFFL.

Post-translational modifications:
Ubiquitinated. Ubiquitination by RFFL promotes proteasomal degradation of PRR5L thereby modifying the substrate-specific activity of the mTORC2 complex. Ubiquitination by RFFL is stimulated by LPA/lysophosphatidic acid.

Similarity:
Belongs to the PROTOR family.

Database links:

Entrez Gene: 79899 Human

Entrez Gene: 505048 Cow

Entrez Gene: 72446 Mouse

Entrez Gene: 362171 Rat

Omim: 611728 Human

SwissProt: Q6MZQ0 Human

SwissProt: A2AVJ5 Mouse

SwissProt: A1L1K1 Rat

Unigene: 19987 Human

Unigene: 24138 Mouse

Unigene: 19060 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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