background:
ZNF474 is a 364 amino acid protein containing one C2H2-type zinc fingers. The gene encoding ZNF474 localizes to chromosome 5 which contains 181 million base pairs and comprises nearly 6% of the human genome. Chromosome 5 is associated with Cockayne syndrome through the ERCC8 gene and familial adenomatous polyposis through the adenomatous polyposis coli (APC) tumor suppressor gene. Treacher Collins syndrome is also chromosome 5-associated and is caused by insertions or deletions within the TCOF1 gene. Deletion of the p arm of chromosome 5 leads to Cri du chat syndrome, while deletion of the q arm or of chromosome 5 altogether is common in therapy-related acute myelogenous leukemias and myelodysplastic syndrome.
Similarity:
Contains 1 C2H2-type zinc finger.
Database links:
Entrez Gene: 133923 Human
SwissProt: Q6S9Z5 Human
Unigene: 646136 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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