background:
Members of the cytochrome b561 (CYB561; MIM 600019) family, including FRRS1, reduce ferric to ferrous iron before its transport from the endosome to the cytoplasm (Vargas et al., 2003 [PubMed 14499595]).[supplied by OMIM, Mar 2008]
Function:
Ferric-chelate reductases reduce Fe(3+) to Fe(2+) before its transport from the endosome to the cytoplasm.
Subcellular Location:
Membrane.
Similarity:
Belongs to the FRRS1 family.
Contains 1 cytochrome b561 domain.
Contains 1 DOMON domain.
Contains 1 reelin domain.
Database links:
Entrez Gene: 391059 Human
Omim: 611578 Human
SwissProt: Q6ZNA5 Human
Unigene: 454779 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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