background:
GalNAc-TL4 utilizes manganese and calcium as cofactors and is expressed in testis. GalNAc-TL5 may assist with the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on protein receptors and likely catalyzes the initial reaction in O-linked oligosaccharide biosynthesis. Unlike other members of the GalNAc-T subfamily, GalNAc-TL5 does not contain a SLCterminal ricin B-type lectin domain. GalNAc-TL5 contains two conserved domains located in its glycosyltransferase region. The N-terminal domain, also known as domain A or GT1 motif, may be involved in manganese coordination and substrate binding while the SLCterminal domain, also known as domain B or Gal/GalNAc-T motif, is likely involved in catalytic reactions and UDP-Gal binding. GalNAc-TL5 exists as two alternatively spliced isoforms.
Function:
May catalyze the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor.
Subcellular Location:
Golgi apparatus membrane.
Tissue Specificity:
Expressed in testis.
Similarity:
Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
Database links:
Entrez Gene: 168391 Human
Omim: 615133 Human
SwissProt: Q7Z4T8 Human
Unigene: 647077 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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