background:
GIN1 is a 522 amino acid protein containing one integrase catalytic domain. Widely expressed, GIN1 is also found in tumors originating from parathyroid gland, colon, stomach, bladder, uterus and prostate. Three isoforms of GIN1 are produced by alternative splicing events. The gene encoding GIN1 maps to human chromsome 5q21.1. Chromosome 5 contains 181 million base pairs and comprises nearly 6% of the human genome. Deletion of the p arm of chromosome 5 leads to Cri du chat syndrome, while deletion of the q arm of chromosome 5 altogether is common in therapy-related acute myelogenous leukemias and myelodysplastic syndrome. Treacher Collins syndrome, Cockayne syndrome and familial adenomatous polyposis are also associated with chromosome 5.
Subcellular Location:
Contains 1 integrase catalytic domain.
Tissue Specificity:
Widely expressed. Also found in tumors originating from parathyroid gland, colon, stomach, bladder, uterus and prostate.
Database links:
Entrez Gene: 54826 Human
Entrez Gene: 252876 Mouse
SwissProt: Q9NXP7 Human
SwissProt: Q8K259 Mouse
Unigene: 4888 Human
Unigene: 86090 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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