Rabbit Anti-GIGYF1/FITC Conjugated antibody

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CDS2; GIGYF1; GRB10-interacting GYF protein 1; GYF1; PERQ amino acid-rich with GYF domain-containing protein 1; PERQ1; PERQ1_HUMAN; Postmeiotic segregation increased 2-like 12; PP3360.

Cat:

SL16244R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Pig,Cow,Horse,Rabbit,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human GIGYF1

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

115kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
PERQ1 is a 1,035 amino acid phosphoprotein that contains one GYF domain and belongs to the PERQ family. Ubiquitously expressed, PERQ1 exhibits highest expression in brain and lung, followed by heart, spleen and kidney. PERQ1 contains a GYF domain in its N-terminal half and a clathrin light chain homology domain in its SLCterminal half. PERQ1 interacts with GRB10, with transient binding increased under IGF-I stimulation, thereby leading to recruitment of the PERQ1/GRB10 complex to the IGF-I receptor. PERQ1 may also increase IRS-1, Shc and IGF-I receptor phosphorylation during IGF-I stimulation, and may act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling.

Function:
May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling. May increase IGF1 receptor phosphorylation under IGF1 stimulation as well as phosphorylation of IRS1 and SHC1.

Similarity:
Belongs to the PERQ family.
Contains 1 GYF domain.

Database links:

Entrez Gene: 64599 Human

Omim: 612064 Human

SwissProt: O75420 Human

Unigene: 414396 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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