background:
GPHB5 is a cystine knot-forming polypeptide and a subunit of the dimeric glycoprotein hormone family (Hsu et al., 2002 [PubMed 12089349]).[supplied by OMIM, Mar 2008]
Function:
GPHB5 is a cystine knot-forming polypeptide and a subunit of the dimeric glycoprotein hormone family. Corticotroph-derived glycoprotein hormone (CGH), also referred to as thyrostimulin, is a noncovalent heterodimer of glycoprotein hormone alpha 2 (GPHA2) and glycoprotein hormone beta 5 (GPHB5).
Subunit:
Heterodimer with GPHA2.
Subcellular Location:
Secreted
Tissue Specificity:
Highly expressed in brain and at low levels in pituitary. Also found in retina, testis and skin but not in pancreas, parotid, kidney, stomach, liver, colon, small intestine, thyroid, brain or adrenal gland. In pituitary, colocalizes with ACTH, suggesting that it is located in corticotrophs.
Post-translational modifications:
N-glycosylated.
Similarity:
Belongs to the glycoprotein hormones subunit beta family.
Database links:
Entrez Gene: 122876 Human
Entrez Gene: 217674 Mouse
Omim: 609652 Human
SwissProt: Q86YW7 Human
SwissProt: Q812B2 Mouse
Unigene: 375028 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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