background:
This gene encodes one of the two pyridoxal enzymes which catalyze a reversible transamination reaction to yield glutamate and pyruvate so these enzymes participate in amino acid metabolism and gluconeogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Function:
Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate.
Tissue Specificity:
Expressed at high levels in muscle, adipose tissue, kidney and brain and at lower levels in the liver and breast.
Similarity:
Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
Alanine aminotransferase subfamily.
Database links:
Entrez Gene: 84706 Human
Entrez Gene: 108682 Mouse
Entrez Gene: 307759 Rat
Omim: 138210 Human
SwissProt: Q8TD30 Human
SwissProt: Q8BGT5 Mouse
Unigene: 92693 Human
Unigene: 200423 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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