background:
Glutathione peroxidase (GPx) enzymes are generally selenium-containing tetrameric glycoproteins that help prevent lipid peroxidation of cell membranes. GPx enzymes reduce lipid hydroperoxides to alcohols, and reduce free hydrogen peroxide to water. GPx members are among the few proteins known in higher vertebrates to contain selenocysteine, which occurs at the active site of glutathione peroxidase and is coded by the nonsense (stop) codon TGA. There are eight GPx homologs (GPx-1–8). GPx-8 (glutathione peroxidase 8), also known as GSHPx-8, is a 209 amino acid single-pass membrane protein. The gene encoding GPx-8 maps to human chromosome 5q11.2 and mouse chromosome 13 D2.2.
Subcellular Location:
Membrane.
Similarity:
Belongs to the glutathione peroxidase family.
Database links:
Entrez Gene: 493869 Human
SwissProt: Q8TED1 Human
Unigene: 289044 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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