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Home > Product > Antibody > Rabbit Anti-Granuphilin/SYTL4/FITC Conjugated antibody
DKFZp451P0116; Exophilin-2; FLJ40960; Granuphilin; SLP4; Synaptotagmin like 4; Synaptotagmin-like protein 4; Sytl4; SYTL4_HUMAN.
Cat:
SL16310R-FITC
Species Reactivity：
Rat,(predicted: Human,Mouse,Dog,Cow,Horse,Rabbit,Sheep,)
Immunogen：
KLH conjugated synthetic peptide derived from human Granuphilin/SYTL4
Format：
Lyophilized or Liquid
Storage instructions：
Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant
Buffer：
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Concentration：
1mg/ml
Clonality：
Polyclonal
Isotype：
IgG
Applications：
ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.
Host：
Rabbit
Calculated MW：
76kDa
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Product PDFs
Datasheet:


background:
This gene encodes a member of the synaptotagmin like protein family. Members of this family are characterized by an N-terminal Rab27 binding domain and SLCterminal tandem C2 domains. The encoded protein binds specific small Rab GTPases and is involved in intracellular membrane trafficking. This protein binds Rab27 and may be involved in inhibiting dense core vesicle exocytosis. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Mar 2010]

Function:
Modulates exocytosis of dense-core granules and secretion of hormones in the pancreas and the pituitary. Interacts with vesicles containing negatively charged phospholipids in a Ca(2+)-independent manner.

Subunit:
Part of a ternary complex containing STX1A and RAB27A. Can bind both dominant negative and dominant active mutants of RAB27A. Binds STXBP1, RAB3A, RAB8A and RAB27B. Interacts with MYO5A (By similarity).

Subcellular Location:
Membrane. Cell membrane. Cytoplasmic vesicle > secretory vesicle membrane. Detected close to the plasma membrane and on secretory granules. In pancreas, interacts with insulin-containing vesicles.

Similarity:
Contains 2 C2 domains.
Contains 1 FYVE-type zinc finger.
Contains 1 RabBD (Rab-binding) domain.

Database links:

Entrez Gene: 94121 Human

Entrez Gene: 27359 Mouse

Entrez Gene: 140594 Rat

Omim: 300723 Human

SwissProt: Q96C24 Human

SwissProt: Q9R0Q1 Mouse

SwissProt: Q8VHQ7 Rat

Unigene: 592224 Human

Unigene: 38674 Mouse

Unigene: 107417 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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