Rabbit Anti-ERAL1/GTP binding protein era homolog/FITC Conjugated antibody

Home > Product > Antibody > Rabbit Anti-ERAL1/GTP binding protein era homolog/FITC Conjugated antibody

CEGA; Conserved ERA like GTPase; Conserved ERA-like GTPase; ERA; Era (E. coli G protein homolog) like 1; Era G protein like 1 (E. coli); Era G protein like 1; ERA W; ERA-like protein 1; ERA-W; Eral1; ERAL1_HUMAN; ERAL1A; ERAW; GTP binding pr

Cat:

SL16364R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Pig,Cow,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human ERAL1/GTP binding protein era homolog

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

43kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
CEGA is a 437 amino acid human homolog of Era. Functioning as a probable GTP-binding protein, ERAL1 contains the same structural domains as its yeast counterpart, namely a conserved BoxA sequence, a SLCterminal KH domain and an N-terminal GTP-binding domain. Due to the high level of structural similarity with Era, ERAL1 may participate in cell cycle events, including cellular proliferation and cell division. ERAL1 contains one KH type-2 domain and is expressed as two isoforms, designated HERA-A and HERA-B, which are produced due to alternative splicing events.

Function:
Probable GTPase that plays a role in the mitochondrial ribosomal small subunit assembly. Specifically binds the 12S mitochondrial rRNA (12S mt-rRNA) to a 33 nucleotide section delineating the 3' terminal stem-loop region. May act as a chaperone that protects the 12S mt-rRNA on the 28S mitoribosomal subunit during ribosomal small subunit assembly.

Subcellular Location:
Mitochondrion matrix. Mitochondrion inner membrane. Localizes on the matrix side on the mitochondrial inner membrane.

Similarity:
Belongs to the Era/MnmE GTP-binding protein family. Era subfamily.
Contains 1 G (guanine nucleotide-binding) domain.
Contains 1 KH type-2 domain.

Database links:

Entrez Gene: 26284 Human

Entrez Gene: 57837 Mouse

Entrez Gene: 363646 Rat

Omim: 607435 Human

SwissProt: O75616 Human

SwissProt: Q9CZU4 Mouse

SwissProt: Q5EBA0 Rat

Unigene: 3426 Human

Unigene: 21096 Mouse

Unigene: 99076 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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