background:
This gene encodes a subunit of an E3 ubiquitin ligase complex that may be involved in meiosis. The encoded protein contains three leucine-rich repeat motifs. [provided by RefSeq, Nov 2012]
Function:
Probably acts as target recruitment subunit in the E3 ubiquitin ligase complex ZER1-CUL2-Elongin BC.
Tissue Specificity:
Expressed in testis, spermatocytes and spermatids (at protein level). Expressed in spermatocytes, spermatids, prostate, skeletal muscle, ovary, small intestine, heart, brain and pancreas.
Similarity:
Belongs to the zyg-11 family.
Contains 5 ARM repeats.
Contains 3 LRR (leucine-rich) repeats.
Database links:
Entrez Gene: 10444 Human
Entrez Gene: 227693 Mouse
SwissProt: Q7Z7L7 Human
SwissProt: Q80ZJ6 Mouse
Unigene: 147950 Human
Unigene: 44526 Mouse
Unigene: 488942 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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