Rabbit Anti-ZNHIT3/FITC Conjugated antibody

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HNF 4a coactivator; Thyroid hormone receptor interactor 3; Thyroid receptor interacting protein 3; TR interacting protein 3; TRIP 3; ZNHI3_HUMAN; TRIP3; Zinc finger HIT domain containing protein 3; Zinc finger HIT type 3; Zinc finger, HIT domain c

Cat:

SL16416R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Rabbit,)

Immunogen：

KLH conjugated synthetic peptide derived from human ZNHIT3

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20℃. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibo

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

18kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
ZNHIT3 is a 155 amino acid protein that contains one HIT-type zinc finger and regulates PPAR?mediated adipocyte differentiation. ZNHIT3 also coactivates HNF-4? and as a thyroid receptor interacting protein, ZNHIT3 interacts with the ligand binding domain of the thyroid receptor. The gene encoding ZNHIT3 maps to human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, though specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes.

Function:
ZNHIT3 functions as a transcriptional coactivator and contains 1 HIT type zinc finger.

Subunit:
Thyroid receptor interacting proteins (TRIPs) specifically interact with the ligand binding domain of the thyroid receptor (TR). Requires the presence of thyroid hormone for its interaction.

Similarity:
Contains 1 HIT-type zinc finger.

Database links:

Entrez Gene: 9326 Human

Omim: 604500 Human

SwissProt: Q15649 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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