background:
ZNHIT2 (zinc finger, HIT-type containing 2), also known as FON, is a 403 amino acid protein that is highly expressed in the seminiferous tubules of testis, with low expression in other tissues. Containing one HIT-type zinc finger, ZNHIT2 is encoded by a gene that maps to human chromosome 11, which comprises approximately 4% of human genomic DNA and is considered a gene and disease association dense chromosome. The chromosome 11 encoded Atm gene is important for regulation of cell cycle arrest and apoptosis following double strand DNA breaks. Atm mutation leads to the disorder known as ataxia-telangiectasia. The blood disorders Sickle cell anemia and thalassemia are caused by HBB gene mutations, while Wilms' tumors, WAGR syndrome and Denys-Drash syndrome are associated with mutations of the WT1 gene. Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema and Smith-Lemli-Opitz syndrome are also associated with defects in chromosome 11-encoded genes.
Tissue Specificity:
Low expression in most tissues; highly expressed in testis.
Similarity:
Contains 1 HIT-type zinc finger.
Database links:
Entrez Gene: 741 Human
Entrez Gene: 539138 Cow
Entrez Gene: 100514699 Pig
Entrez Gene: 309177 Rat
Omim: 604575 Human
SwissProt: Q2TBW5 Cow
SwissProt: Q9UHR6 Human
Unigene: 41757 Cow
Unigene: 121025 Human
Unigene: 19362 Pig
Unigene: 18470 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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