Rabbit Anti-HDGFRP3/FITC Conjugated antibody

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CGI 142; HDGF 2; HDGF-2; HDGF2; HDGFRP 3; Hdgfrp3; HDGR3_HUMAN; Hepatoma derived growth factor 2; Hepatoma derived growth factor related protein 3; Hepatoma-derived growth factor 2; Hepatoma-derived growth factor-related protein 3; HRP 3; HRP-

Cat:

SL16464R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Chicken,Dog,Pig,Cow,Horse,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human HDGFRP3

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

23kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
Hepatoma derived growth factor (HDGF) is the original member of a family of polypeptides designated HDGF-related proteins (HRPs). HDGF was initially characterized as a secreted mitogen from the Huh-7 human hepatoma cell line. This nuclear targeted vascular smooth muscle cell mitogen (VSM) is a heparin-binding protein that is highly expressed in tumor cells, where it stimulates proliferation. HDGF is also reported to be involved in organ development and lung remodeling after injury by promoting proliferation of lung epithelial cells. During development, HDGF expression is high in the nucleus and cytoplasm of smooth muscle and endothelial cells. The HRP family contains four proteins, HRP-1, HRP-2, HRP-3 and HRP-4. HRP-1 and HRP-4 are expressed only in testis, while HRP-2 is widely expressed in different tissues. HRP-3 can be found solely in the nervous system. Specifically it is strongly expressed in bulbus, olfactorius, piriform cotrex and amygdala complex, while HRP-2 in brain is located in the the thalamus, prefrontal and parietal cortex, neurohypophysis and cerebellum. In the central nervous system, HRPs play a role in neuron proliferation and cell survival.

Function:
Enhances DNA synthesis and may play a role in cell proliferation.

Subcellular Location:
Nucleus.

Tissue Specificity:
Detected in testis, heart, spinal cord and brain.

Similarity:
Belongs to the HDGF family.
Contains 1 PWWP domain.

Database links:

Entrez Gene: 50810 Human

Entrez Gene: 29877 Mouse

Entrez Gene: 252941 Rat

SwissProt: Q9Y3E1 Human

SwissProt: Q9JMG7 Mouse

SwissProt: Q923W4 Rat

Unigene: 513954 Human

Unigene: 392934 Mouse

Unigene: 17383 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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