Rabbit Anti-HEY1/FITC Conjugated antibody

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Basic helix loop helix protein OAF1; bHLHb31; Cardiovascular helix loop helix factor 2; Cardiovascular helix loop-helix factor 2; Cardiovascular helix-loop-helix factor 2; CHF 2; CHF-2; CHF2; Class B basic helix-loop-helix protein 31; Hairy and e

Cat:

SL16500R-FITC

Species Reactivity：

Rat,(predicted: Human,Mouse,Dog,Cow,Horse,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human HEY1

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

34kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
This gene encodes a nuclear protein belonging to the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcriptional repressors. Expression of this gene is induced by the Notch and c-Jun signal transduction pathways. Two similar and redundant genes in mouse are required for embryonic cardiovascular development, and are also implicated in neurogenesis and somitogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]

Function:
Downstream effector of Notch signaling which may be required for cardiovascular development. Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6.

Subcellular Location:
Nucleus.

Tissue Specificity:
Expressed in the somitic mesoderm, the central nervous system, the kidney, the heart, nasal epithelium, and limbs.

Similarity:
Belongs to the HEY family.
Contains 1 basic helix-loop-helix (bHLH) domain.
Contains 1 Orange domain.

Database links:

Entrez Gene: 23462 Human

Entrez Gene: 403420 Dog

Entrez Gene: 15213 Mouse

Entrez Gene: 155437 Rat

Omim: 602953 Human

SwissProt: Q9TSZ2 Dog

SwissProt: Q9Y5J3 Human

SwissProt: Q9WV93 Mouse

Unigene: 234434 Human

Unigene: 29581 Mouse

Unigene: 98202 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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