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Rabbit Anti-IMPG1/FITC Conjugated antibody
background:
This gene encodes a protein that is a major component of the retinal interphotoreceptor matrix. The encoded protein is a proteoglycan that is thought to play a role in maintaining viability of photoreceptor cells and in adhesion of the neural retina to the retinal pigment epithelium. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Function:
May interact with hyaluronan which may serve to form a basic macromolecular scaffold comprising the insoluble interphotoreceptor matrix.
Subcellular Location:
Secreted.
Tissue Specificity:
Abundantly expressed in retina where it is specifically expressed by cone and rod photoreceptor cells. Localizes to cone and rod photoreceptor cells surrounding the interphotoreceptor matrix of the retina.
Post-translational modifications:
The N-terminus is blocked.
Highly glycosylated (N- and O-linked carbohydrates and sialic acid).
Similarity:
Contains 2 SEA domains.
Database links:
Entrez Gene: 3617 Human
Entrez Gene: 63859 Mouse
Entrez Gene: 66014 Rat
Omim: 602870 Human
SwissProt: Q17R60 Human
SwissProt: Q8R1W8 Mouse
SwissProt: Q9ET62 Rat
Unigene: 590893 Human
Unigene: 422780 Mouse
Unigene: 64488 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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