background:
Translational regulator that ensures constant high levels of translation under amino acid starvation. Acts by interacting with GCN1/GCN1L1, thereby preventing activation of GCN2 protein kinases (EIF2AK1 to 4) and subsequent down-regulation of protein synthesis.
Function:
Translational regulator that ensures constant high levels of translation under amino acid starvation. Acts by interacting with GCN1/GCN1L1, thereby preventing activation of GCN2 protein kinases (EIF2AK1 to 4) and subsequent down-regulation of protein synthesis (By similarity). May be required to regulate translation in specific neuronal cells under amino acid starvation conditions by preventing GCN2 activation and therefore ATF4 synthesis (By similarity). Through its action on GCN2, may also facilitate neuritogenesis (By similarity).
Subunit:
Interacts with GCN1/GCN1L1 (By similarity).
Subcellular Location:
Cytoplasm (By similarity). Note=May be associated with polysomes (By similarity).
Tissue Specificity:
Widely expressed. Expressed at high level in brain.
Similarity:
Belongs to the IMPACT family.
Contains 1 RWD domain.
Database links:
Entrez Gene: 55364 Human
Entrez Gene: 100009333 Rabbit
SwissProt: Q9P2X3 Human
SwissProt: Q5GFD8 Rabbit
Unigene: 515317 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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