Rabbit Anti-INT11/CPSF3L/FITC Conjugated antibody

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2410006F12Rik; AU044035; Cleavage and polyadenylation specific factor 3 like; Cleavage and polyadenylation-specific factor 3-like protein; CPSF3 like protein; CPSF3-like protein; CPSF3L; CPSF73L; FLJ13294; FLJ20542; Human integrator complex subu

Cat:

SL16677R-FITC

Species Reactivity：

Mouse,Rat,(predicted: Human,Horse,Zebrafish,Rhesus monkey, Gorilla, Opossum, Orangutan, Elephant)

Immunogen：

KLH conjugated synthetic peptide derived from human INT11/CPSF3L

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

68kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
The Integrator complex contains at least 12 subunits and associates with the SLCterminal domain of RNA polymerase II large subunit (POLR2A; MIM 36660) and mediates the 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 36136) and U2 (RNU2; MIM 36690). INTS11, or CPSF3L, is the catalytic subunit of the Integrator complex (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]

Function:
Catalytic component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the SLCterminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates the snRNAs 3' cleavage.

Subunit:
Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, CPSF3L/INTS11 and INTS12.

Subcellular Location:
Nucleus. Cytoplasm.

Tissue Specificity:
Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. INTS11 subfamily.

Similarity:
Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. INTS11 subfamily. {ECO:0000305}.

Database links:

Entrez Gene: 54973 Human

Entrez Gene: 71957 Mouse

Omim: 611354 Human

SwissProt: Q5TA45 Human

SwissProt: Q9CWS4 Mouse

Unigene: 6449 Human

Unigene: 475128 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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