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Rabbit Anti-IQCF6/FITC Conjugated antibody
background:
Encoding more than 700 genes, chromosome 15 is made up of approximately 106 million base pairs and is about 3% of the human genome. Angelman and Prader-Willi syndromes are associated with loss of function or deletion of genes in the 15q11-q13 region. In the case of Angelman syndrome, this loss is due to inactivity of the maternal 15q11-q13 encoded UBE3A gene in the brain by either chromosomal deletion or mutation. In cases of Prader-Willi syndrome, there is a partial or complete deletion of this region from the paternal copy of chromosome 15. Tay-Sachs disease is a lethal disorder associated with mutations of the HEXA gene, which is encoded by chromosome 15. Marfan syndrome is associated with chromosome 15 through the FBN1 gene.
Function:
May play a regulatory role in spermatogenesis.
Tissue Specificity:
Expressed in fetal and adult testis, in germ cells but not somatic cells.
Similarity:
Contains 1 IQ domain.
Database links:
Entrez Gene: 64799 Human
Omim: 612523 Human
SwissProt: Q86VS3 Human
Unigene: 657894 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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