background:
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. Although the function of the protein is unknown, the RING domain suggests that the protein may have DNA-binding activity. The gene localizes to the major histocompatibility complex (MHC) class I region on chromosome 6. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2011]
Function:
TRIM26 is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. Although the function of the protein is unknown, the RING domain suggests that the protein may have DNA-binding activity.
Subcellular Location:
cytoplasmic
Similarity:
Belongs to the TRIM/RBCC family.
Contains 1 B box-type zinc finger.
Contains 1 B30.2/SPRY domain.
Contains 1 RING-type zinc finger.
Database links:
Entrez Gene: 462536 Chimpanzee
Entrez Gene: 7726 Human
Entrez Gene: 22670 Mouse
Entrez Gene: 309586 Rat
Omim: 600830 Human
SwissProt: Q7YR34 Chimpanzee
SwissProt: Q12899 Human
SwissProt: Q99PN3 Mouse
SwissProt: P62603 Rat
Unigene: 485041 Human
Unigene: 731863 Human
Unigene: 34587 Mouse
Unigene: 163420 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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