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Rabbit Anti-TRIM5 gamma/FITC Conjugated antibody
background:
Isoform Alpha is a retrovirus restriction factor, which mediates species-specific, early block to retrovirus infection. Targets retroviral capsid soon after entry into the cell, and prevents reverse transcription of the virus RNA genome. Isoform Alpha trimers may make multiple contacts with the hexameric lattice of CA proteins which constitute the surface of retrovirion core, and somehow inactivate the virus. Restricts efficiently infection by N-MLV, but not HISLV1. May have E3 ubiquitin-protein ligase activity.
Subcellular Location:
Cytoplasm > P-body. Cytoplasmic bodies.
Post-translational modifications:
Ubiquitinates itself in a RING finger- and UBE2D2-dependent manner (in vitro).
Similarity:
Belongs to the TRIM/RBCC family.
Contains 1 B box-type zinc finger.
Contains 1 B30.2/SPRY domain.
Contains 1 RING-type zinc finger.
Database links:
Entrez Gene: 85363 Human
Omim: 608487 Human
SwissProt: Q9C035 Human
Unigene: 370515 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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