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Rabbit Anti-KREMEN1/FITC Conjugated antibody
background:
This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein is a component of a membrane complex that modulates canonical WNT signaling through lipoprotein receptor-related protein 6 (LRP6). It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene. [provided by RefSeq, Jul 2008]
Function:
Receptor for Dickkopf protein. Cooperates with Dickkopf to block Wnt/beta-catenin signaling (By similarity). {ECO:0000250}.
Subcellular Location:
Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Similarity:
Contains 1 CUB domain.
Database links:
Entrez Gene: 83999 Human
Omim: 609898 Human
SwissProt: Q96MU8 Human
Unigene: 229335 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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