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Rabbit Anti-CRHR1/FITC Conjugated antibody
background:
This gene encodes a G-protein coupled receptor that binds neuropeptides of the corticotropin releasing hormone family that are major regulators of the hypothalamic-pituitary-adrenal pathway. The encoded protein is essential for the activation of signal transduction pathways that regulate diverse physiological processes including stress, reproduction, immune response and obesity. Alternative splicing results in multiple transcript variants one of which is a non-coding read-through transcript with the neighboring gene MGC57346.
Function:
Receptor for corticotropin releasing factor (CRH). Shows high-affinity CRF binding. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
Subunit:
Interacts (via N-terminal extracellular domain) with CRF and UCN.
Subcellular Location:
Cell membrane; Multi-pass membrane protein.
Tissue Specificity:
Predominantly expressed in the cerebellum, pituitary, cerebral cortex and olfactory lobe.
Post-translational modifications:
SLCterminal Ser or Thr residues may be phosphorylated.
Similarity:
Belongs to the G-protein coupled receptor 2 family.
Database links:
Entrez Gene: 1394 Human
Entrez Gene: 12921 Mouse
Entrez Gene: 58959 Rat
Omim: 122561 Human
SwissProt: P34998 Human
SwissProt: P35347 Mouse
SwissProt: P35353 Rat
Unigene: 417628 Human
Unigene: 1892 Mouse
Unigene: 10499 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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