background:
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. The KCNH5 gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit of a voltage-gated non-inactivating delayed rectifier potassium channel. KCNH5 is not expressed in differentiating myoblasts.
Subunit:
The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits. Heteromultimer with KCNH1/EAG (Probable).
Subcellular Location:
Cell Membrane: multi-pass membrane protein.
Tissue Specificity:
Detected in brain, skeletal muscle, heart,placenta, lung and liver, and at low levels in kidney.
Similarity:
Belongs to the potassium channel family.
Contains 1 cyclic nucleotide-binding domain.
Contains 1 PAS (PER-ARNT-SIM) domain.
Contains 1 cyclic nucleotide-binding domain.
] Contains 1 PAS (PER-ARNT-SIM) domain.
Database links:
Entrez Gene: 27133 Human
Entrez Gene: 238271 Mouse
Entrez Gene: 171146 Rat
Omim: 605716 Human
SwissProt: Q8NCM2 Human
SwissProt: Q6NZH0 Mouse
SwissProt: Q920E3 Mouse
SwissProt: Q9EPI9 Rat
Unigene: 27043 Human
Unigene: 48753 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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