Rabbit Anti-KCNH3/FITC Conjugated antibody

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BEC1; Brain-specific eag-like channel 1; ELK channel 2; ELK2; Ether-a-go-go-like potassium channel 2; Kv12.2; Melk2; Potassium voltage-gated channel, subfamily H (eag-related), member 3; Voltage-gated potassium channel subunit Kv12.2.

Cat:

SL16884R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Rabbit,)

Immunogen：

KLH conjugated synthetic peptide derived from human KCNH3

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

117kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
Voltage gated potassium (Kv) channels represent the most complex class of voltage gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. KCNH3 is a pore forming (alpha) subunit of voltage-gated potassium channel. It elicits an outward current with fast inactivation.

Subunit:
The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits.

Subcellular Location:
Membrane; Multipass membrane protein.

Tissue Specificity:
Detected only in brain, in particular in the telencephalon. Detected in the cerebral cortex, occipital pole, frontal and temporal lobe, putamen, amygdala, hippocampus and caudate nucleus.

Similarity:
Contains 1 cyclic nucleotide-binding domain.
Contains 1 PAC (PAS-associated SLCterminal) domain.
Contains 1 PAS (PER-ARNT-SIM) domain.

Database links:

Entrez Gene: 23416 Human

Entrez Gene: 16512 Mouse

Entrez Gene: 27150 Rat

Omim: 604527 Human

SwissProt: Q9ULD8 Human

SwissProt: Q9WVJ0 Mouse

SwissProt: O89047 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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