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Rabbit Anti-KCNMB2/FITC Conjugated antibody
background:
MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which decreases the activation time of MaxiK alpha subunit currents. Alternative splicing results in multiple transcript variants of this gene. Additional variants are discussed in the literature, but their full length nature has not been described. [provided by RefSeq, Jul 2013]
Function:
Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Acts as a negative regulator that confers rapid and complete inactivation of KCNMA1 channel complex. May participate in KCNMA1 inactivation in chromaffin cells of the adrenal gland or in hippocampal CA1 neurons.
Subcellular Location:
Membrane.
Tissue Specificity:
Expressed in kidney, heart and brain. Highly expressed in ovary. Expressed at low level in other tissues.
Post-translational modifications:
N-glycosylated.
Similarity:
Belongs to the KCNMB (TC 8.A.14.1) family. KCNMB2 subfamily.
Database links:
Entrez Gene: 10242 Human
Entrez Gene: 72413 Mouse
Entrez Gene: 294961 Rat
Omim: 605214 Human
SwissProt: Q9Y691 Human
SwissProt: Q9CZM9 Mouse
SwissProt: Q811Q0 Rat
Unigene: 478368 Human
Unigene: 64790 Mouse
Unigene: 220612 Rat
Unigene: 92476 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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