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Rabbit Anti-KCNV1/FITC Conjugated antibody
background:
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium voltage-gated channel subfamily V. This protein is essentially present in the brain, and its role might be to inhibit the function of a particular class of outward rectifier potassium channel types. [provided by RefSeq, Jul 2008]
Function:
Potassium channel subunit that does not form functional channels by itself. Modulates KCNB1 and KCNB2 channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. Can down-regulate the channel activity of KCNB1, KCNB2, KCNC4 and KCND1, possibly by trapping them in intracellular membranes.
Subcellular Location:
Cell membrane. Has to be associated with another potassium channel subunit to get inserted in the plasma membrane. Remains intracellular in the absence of KCNB2.
Tissue Specificity:
Detected in brain.
Post-translational modifications:
Phosphorylated by protein kinase C. Phosphorylation of the SLCterminal domain increases channel activity.
Similarity:
Belongs to the potassium channel family. V (TC 1.A.1.2) subfamily. Kv8.1/KCNV1 sub-subfamily.
Database links:
Entrez Gene: 27012 Human
Entrez Gene: 505732 Cow
Entrez Gene: 67498 Mouse
Entrez Gene: 60326 Rat
Omim: 608164 Human
SwissProt: Q0P583 Cow
SwissProt: Q6PIU1 Human
SwissProt: Q8BZN2 Mouse
SwissProt: P97557 Rat
Unigene: 13285 Human
Unigene: 300079 Mouse
Unigene: 42920 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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