background:
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium voltage-gated channel subfamily V. This member is identified as a 'silent subunit', and it does not form homomultimers, but forms heteromultimers with several other subfamily members. Through obligatory heteromerization, it exerts a function-altering effect on other potassium channel subunits. This protein is strongly expressed in pancreas and has a weaker expression in several other tissues. [provided by RefSeq, Jul 2008]
Function:
Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values.
Subunit:
Heteromultimer with KCNB1, KCNC1 and KCNF1. Does not form homomultimers.
Subcellular Location:
Cell membrane. Has to be associated with KCNB1 or possibly another partner to get inserted in the plasma membrane. Remains intracellular in the absence of KCNB1.
Tissue Specificity:
Detected in lung, liver, kidney, pancreas, spleen, thymus, prostate, testis, ovary and colon.
DISEASE:
Defects in KCNV2 are the cause of cone dystrophy retinal type 3B (RCD3B) [MIM:610356]; also called cone dystrophy with night blindness and supernormal rod responses KCNV2-related. RCD3B is a rare form of cone dystrophy associated with supernormal rod responses. The disorder is characterized by reduced visual acuity, photoaversion, night blindness, and abnormal color vision. At an early age, the retina shows subtle depigmentation at the macula and, later, more obvious areas of atrophy.
Similarity:
Belongs to the potassium channel family. V (TC 1.A.1.2) subfamily. Kv8.2/KCNV2 sub-subfamily.
Database links:
Entrez Gene: 169522 Human
Entrez Gene: 48595 Mouse
Omim: 607604 Human
SwissProt: Q8TDN2 Human
SwissProt: Q8CFS6 Mouse
Unigene: 624689 Human
Unigene: 660831 Human
Unigene: 269759 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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Blank control(blue): Hepg2 Cells(fixed with 2% paraformaldehyde (10 min)). Primary Antibody: Rabbit Anti-KCNV2/FITC Conjugated antibody (SL16921R /FITC), Dilution: 3μg in 100 μL 1X PBS containing 0.5% BSA; Isotype Control Antibody: Rabbit IgG/FITC(orange) ,used under the same conditions.
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