Rabbit Anti-Myosin-10 /FITC Conjugated antibody

Home > Product > Antibody > Rabbit Anti-Myosin-10 /FITC Conjugated antibody

MYH10_HUMAN; Myosin-10; Cellular myosin heavy chain, type B; Myosin heavy chain 10; Myosin heavy chain, non-muscle IIb; Non-muscle myosin heavy chain B; NMMHC-B; Non-muscle myosin heavy chain IIb; NMMHC II-b; NMMHC-IIB.

Cat:

SL10907R-FITC

Species Reactivity：

Mouse,Rat,(predicted: Human,Pig,Cow,Rabbit,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human Myosin-10

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

229kDa

prev next

Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
Feedback Wall

Function:
Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the central part but not the margins of spreading cells), and lamellipodial extension; this function is mechanically antagonized by MYH9.

Subunit:
Myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLSLC2). Interacts with PLEKHG6. Interacts with ECM29. Interacts with KIF26B (By similarity). Interacts with LARP6. Interacts with MCC.

Subcellular Location:
Cell projection, lamellipodium. Note=Colocalizes with MCC at the leading edge of migrating cells.

Tissue Specificity:
Isoform 1 is expressed in cerebellum and spinal chord. Isoform 2 is expressed in cerebrum and retina. Isoform 3 is expressed in the cerebrum and to a much lower extent in cerebellum.

Post-translational modifications:
Phosphorylated by ABL2 (By similarity).

Similarity:
Contains 1 IQ domain.
Contains 1 myosin head-like domain.

Database links:

Entrez Gene: 4628 Human

Entrez Gene: 317655 Cow

Entrez Gene: 77579 Mouse

Entrez Gene: 79433 Rat

Omim: 160776 Human

SwissProt: Q27991 Cow

SwissProt: P35580 Human

SwissProt: Q5SV64 Mouse

SwissProt: Q61879 Mouse

SwissProt: Q8BXF2 Mouse

SwissProt: Q9JLT0 Rat

Unigene: 16355 Human

Unigene: 218233 Mouse

Unigene: 98166 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Product Feedback Wall