Rabbit Anti-KIF26A/FITC Conjugated antibody

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DKFZP434N178; FLJ22753; KI26A_HUMAN; KIAA1236; KIF 26A; KIF26A; KIF26A variant protein; Kinesin family member 26A; Kinesin like protein KIF26A; Kinesin-like protein KIF26A.

Cat:

SL17053R-FITC

Species Reactivity：

Human,(predicted: Mouse,Rat,Cow,Horse,)

Immunogen：

KLH conjugated synthetic peptide derived from human KIF26A

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

195kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
The kinesins constitute a large family of microtubule-dependent motor proteins, which are responsible for the distribution of numerous organelles, vesicles and macromolecular complexes throughout the cell. Individual kinesin members play crucial roles in cell division, intracellular transport and membrane trafficking events including endocytosis and transcytosis. KIF26A (kinesin family member 26A) is a 1,882 amino acid protein that contains one N-terminal kinesin-motor domain and belongs to the kinesin-like protein family. The kinesin-motor domain is responsible for the ATP-dependent movement of KIF26A across microtubules.

Function:
Atypical kinesin that plays a key role in enteric neuron development. Acts by repressing a cell growth signaling pathway in the enteric nervous system development, possibly via its interaction with GRB2 that prevents GRB2-binding to SHC, thereby attenating the GDNF-Ret signaling. Binds to microtubules but lacks microtubule-based motility due to the absence of ATPase activity.

Subcellular Location:
Cytoplasm > cytoskeleton.

Similarity:
Belongs to the kinesin-like protein family. KIF26 subfamily.
Contains 1 kinesin-motor domain.

Database links:

Entrez Gene: 26153 Human

Omim: 613231 Human

SwissProt: Q9ULI4 Human

Unigene: 134970 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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