Rabbit Anti-LAX1/FITC Conjugated antibody

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FLJ20340; LAT like membrane associated protein; LAX; LAX1_HUMAN; Linker for activation of X cells; Lymphocyte transmembrane adaptor 1; Membrane associated adapter protein LAX; OTTHUMP00000034094.

Cat:

SL17111R-FITC

Species Reactivity：

(predicted: Human,)

Immunogen：

KLH conjugated synthetic peptide derived from human LAX1

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

44kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
LAX1 is a 398 amino acid single-pass type III membrane protein that negatively regulates lymphocyte signaling. LAX1 is expressed in lymphoid tissues including thymus, spleen and peripheral blood leukocytes, along with several B-cell, T-cell, natural killer and monocyte cell lines. When stimulated by B or T cells, LAX1 becomes dramatically upregulated and also interacts with GRB2, Gads and PI 3-kinase p85 upon phosphorylation. LAX1 exists as two alternatively spliced isoforms that are encoded by a gene located on human chromosome 1. Chromosome 1 houses a large number of disease-associated genes, including those that are involved in familial adenomatous polyposis, Stickler syndrome, Parkinson’s disease, Gaucher disease, schizophrenia and Usher syndrome.

Function:
LAX1 negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and BCR (B-cell antigen receptor)-mediated signaling in B-cells.

Subunit:
When phosphorylated, interacts with GRB2, PIK3R1 and GRAP2.

Subcellular Location:
Cell Membrane; Single-pass type III membrane protein.

Tissue Specificity:
Expressed in spleen, thymus, and peripheral blood leukocytes. Expressed in several B-, T-, NK and monocyte cell lines.

Post-translational modifications:
Phosphorylated on tyrosines by Syk, Lck or ZAP70 upon TCR or BCR activation; which leads to the recruitment of GRB2, PIK3R1 and GRAP2.

Database links:

Entrez Gene: 5980 Human

SwissProt: Q8IWV1 Human

Unigene: 272794 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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