Rabbit Anti-TRMT6/FITC Conjugated antibody

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KIAA1153; Adenine N; CGI 09; CGI09; GCD10; Gcd10p; KIAA1153; MGC5029; TRM6; TRM6_HUMAN; trmt6; tRNA (adenine-N(1)-)-methyltransferase non-catalytic subunit TRM6; tRNA methyltransferase 6; tRNA methyltransferase 6 homolog (S. cerevisiae); tRN

Cat:

SL17146R-FITC

Species Reactivity：

Mouse,(predicted: Human,Rat,Dog,Pig,Cow,Horse,Rabbit,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human TRMT6

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

56kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
This gene encodes a member of the tRNA methyltransferase 6 protein family. A similar protein in yeast is part of a two component methyltransferase, which is involved in the posttranslational modification that produces the modified nucleoside 1-methyladenosine in tRNAs. Modified 1-methyladenosine influences initiator methionine stability and may be involved in the replication of human immunodeficiency virus type 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Function:
Substrate-binding subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.

Subunit:
tRNA (adenine-N(1)-)-methyltransferase is a heterodimer of TRM6 and TRM61.

Subcellular Location:
Nucleus.

Tissue Specificity:
Expressed in brain, liver, testis and ovary.

Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.

Similarity:
Belongs to the TRM6/GCD10 family.

Database links:

Entrez Gene: 51605 Human

SwissProt: Q9UJA5 Human

Unigene: 128791 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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