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Rabbit Anti-TRMT61B/FITC Conjugated antibody
background:
The second largest human chromosome, 2 consists of 237 million bases encoding over 1,400 genes and making up approximately 8% of the human genome. A number of genetic diseases are linked to genes on chromosome 2. Harlequin icthyosis, a rare and morbid skin deformity, is associated with mutations in the ABCA12 gene. The lipid metabolic disorder sitosterolemia is associated with ABCG5 and ABCG8. An extremely rare recessive genetic disorder, Alstr鰉 syndrome is due to mutations in the ALMS1 gene. Interestingly, chromosome 2 contains what appears to be a vestigial second centromere and vestigial telomeres which gives credence to the hypothesis that human chromosome 2 is the result of an ancient fusion of two ancestral chromosomes seen in modern form today in apes. The FLJ20628 gene product has been provisionally designated FLJ20628 pending further characterization.
Function:
Biological process: tRNA processing
Subunit:
Homooligomer; in contrast to TRMT61A, does not for a heterotetramer.
Subcellular Location:
Mitochondrion
Similarity:
Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.
Database links:
Entrez Gene: 55006 Human
SwissProt: Q9BVS5 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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