Home
>
Product
>
Antibody
>
Rabbit Anti-Tropomodulin 3/FITC Conjugated antibody
background:
Originally isolated from human erythrocytes, the tropomodulin (TMOD) family of proteins cap the pointed end of Actin filaments. A component of the membrane skeleton, tropomodulin binds to the amino-terminus of Tropomyosin, which coats the surface of Actin, and thus blocks the elongation and depolymerization of Actin filaments. Four tropomodulin isoforms, tropomodulin 1-4, have been characterized in humans. Tropomodulin expression is isoform-specific; tropomodulin 3 is expressed ubiquitously, whereas tropomodulin 2 and tropomodulin 4 are expressed in neuronal tissue and muscle, respectively. Ubiquitous expression of seven tropomodulin 3 transcripts, ranging in size between 1 and 9.5 kb, have been identified by Northern Blot analysis on human tissues. The human TMOD3 gene maps to chromosome 15q21.2, within the same region as the gene for amyotrophic lateral sclerosis 5 (ALS5), and encodes a 352 amino acid protein. Tmod3, the mouse homolog to human TMOD3, is present as early as day 7 in embryonic development and is expressed throughout development.
Function:
Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton.
Subunit:
Binds to the N-terminus of tropomyosin and to actin.
Subcellular Location:
Cytoplasm > cytoskeleton.
Tissue Specificity:
Ubiquitous.
Similarity:
Belongs to the tropomodulin family.
Database links:
Entrez Gene: 29766 Human
Entrez Gene: 50875 Mouse
Entrez Gene: 397556 Pig
Entrez Gene: 300838 Rat
Omim: 605112 Human
SwissProt: Q9NYL9 Human
SwissProt: Q9JHJ0 Mouse
Unigene: 4998 Human
Unigene: 38445 Mouse
Unigene: 146101 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
|
|