Rabbit Anti-SAV1/FITC Conjugated antibody

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1700040G09Rik; 45 kDa WW domain protein; hWW 45; hWW45; Protein salvador homolog 1; salvador homolog 1 (Drosophila); Salvador homolog 1; SAV 1; SAV; SAV1; SAV1_HUMAN; WW 45; WW domain containing; WW45; WW45 protein; WWP 4; WWP4.

Cat:

SL17245R-FITC

Species Reactivity：

Rat,(predicted: Human,Mouse,Dog,Pig,Cow,Horse,Rabbit,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human SAV1

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

45kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein with two WW domains, a SARAH domain, and a coiled-coil region and is ubiquitously expressed in adult tissues. This protein binds to MST1 (mammalian sterile 20-like kinase 1) and promotes MST1-induced apoptosis. It has also been shown to bind to HAX1 (hematopoietic cell-specific protein 1 (HS1)-associated protein X-1) and to attenuate the anti-apoptotic effects of HAX1. Studies in human and mouse suggest this gene acts as a tumor suppressor. [provided by RefSeq, Aug 2012]

Function:
Regulator of MST1/MST2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. SAV1 is required for MST1/MST2 activation and promotes cell-cycle exit and terminal differentiation in developing epithelial tissues.

Subcellular Location:
Nucleus. Cytoplasm.

Tissue Specificity:
Ubiquitously expressed in adult tissues with highest expression in the pancreas, aorta and interventricular septum and lowest expression in skeletal muscle. Expression was higher in fetal than in the adult heart. Expressed in various cell lines.

Post-translational modifications:
Phosphorylated by STK3 and STK4. Phosphorylation is not required for SAV1 stability and may increase the number of protein binding sites on the scaffold molecule.

Similarity:
Contains 1 SARAH domain.
Contains 2 WW domains.

Database links:

Entrez Gene: 60485 Human

Entrez Gene: 12810 Mouse

Entrez Gene: 299116 Rat

Omim: 607203 Human

SwissProt: Q9H4B6 Human

SwissProt: Q8VEB2 Mouse

SwissProt: A4V8B4 Rat

Unigene: 642842 Human

Unigene: 39096 Mouse

Unigene: 14087 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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